Vitamin k antidote for7/19/2023 ![]() Vitamin K deficiency can be due to deficient biosynthesis in the intestinal tract that leads to deficient bioavailability in various pathological situations such as: medicine induced intestinal dysbacteriosis, especially after antibiotic treatment enteropathies accompanied by heavy diarrhea mechanical jaundice with acholia that leads to reduction or absence of bile secretion in the intestinal tract prematurity of the newborns associated with subnormal synthesis of vitamin K in intestinal tract severe liver disease (acute dystrophies, hepatitis, cirrhosis) autoimmune disorders due to double antiviral therapy with Peginterferon and Ribavirin in patients with hepatitis C virus infection. Vitamin K-dependent coagulopathies are rather common in clinical practice, especially in cases of overdose of orally prescribed anticoagulants of indirect-action, also known as the vitamin K antagonists (VKA). Reasons for vitamin K antagonists–dependent coagulopathy cases With early diagnosis and prescription of appropriate therapy, prognosis is favorable. Even when pathological vitamin K deficiency is not determined, appropriate and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. Differential diagnosis is primarily based on patient statements before additional causes of vitamin K deficiency are explored. ![]() This article discusses different types of acquired vitamin K-dependent coagulopathy. Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. ![]() Physicians often come across with cases of vitamin K antagonists–dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide).
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